Modulation of sympathetic activity and heart rate variability by ivabradine
نویسندگان
چکیده
منابع مشابه
Modulation of sympathetic activity and heart rate variability by ivabradine.
AIMS Bradycardic agents are currently used in the treatment of angina and heart failure; direct information on their effects on cardiac sympathetic nerve activity (SNA) may be relevant to their chronic use. The present study evaluates the effect of pacemaker inhibition on SNA; direct nerve recordings and indirect autonomic indexes are compared. METHODS AND RESULTS Experiments were performed i...
متن کاملIvabradine: heart rate and left ventricular function.
intravenous administration of ivabradine caused no serious adverse events, with only four mild adverse events possibly related to ivabradine, all of which resolved spontaneously on the same day. Thus, Manz et al. [1] demonstrated that ivabradine is not just another reducer of heart rate. It is the only compound that can reduce heart rate without affecting any other hemodynamic parameter and wit...
متن کاملSympathetic reinnervation and heart rate variability after cardiac transplantation.
BACKGROUND Heart rate variability is thought to measure autonomic modulation, but the relation has never been demonstrated directly in humans. AIM To test the hypothesis that increased low frequency heart rate variability reflects sympathetic reinnervation after cardiac transplantation. PATIENTS 24 cardiac transplant recipients at the time of routine surveillance coronary angiography two or...
متن کاملHeart rate variability and muscle sympathetic nerve activity response to acute stress: the effect of breathing.
Previous research has suggested a relationship between low-frequency power of heart rate variability (HRV; LF in normalized units, LFnu) and muscle sympathetic nerve activity (MSNA). However, investigations have not systematically controlled for breathing, which can modulate both HRV and MSNA. Accordingly, the aims of this experiment were to investigate the possibility of parallel responses in ...
متن کاملSympathetic reinnervation after heart transplantation, assessed by iodine-123 metaiodobenzylguanidine imaging, and heart rate variability.
OBJECTIVE Complete allograft denervation occurs during heart transplantation. Partial ventricular sympathetic reinnervation may develop one year or later after transplantation and can be measured with iodine-123-meta-iodobenziylguanidine (MIBG) uptake. Aim of this study was to assess sinus node sympathetic reinnervation measured with heart rate variability and ventricular sympathetic reinnervat...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2015
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvv180